Rosetta 3.0 is out!!!

Fellow protein modellers, Rosetta 3.0 is out. New and improved Rosetta 3.0 now is even easier to compiler (even in non favored platforms such as Mac OS X 10.6, using gcc 4.0.1).

I just got it yesterday and compiled it in my Macbook Pro as well as in a Mac Pro quad core. I was far easier that ever before. I haven't been folowing the development cycles closely but I can tell that a lot of effort has been poured into this release. Some of the options and flags for running the various modes of rosetta have changed, ie. instead of adding a flag preceded by a "-" now the flags follow a tree-like system. Something that looks like this docking:dock_pert.

The download of all of rosetta 3.0 (antibody docking, source, database, etc) is heafty one around 700 Mbs but worth every bit of it. I am in the middle of a project that will benefit from a atomic model of a dimer (80 kDa per monomer) and I am running it as we speak and with basic flags (-dock_pert 10 8 -ex1 -dock_mcm -out:file:fullatom) I get 10 models in 2411 seconds. That sounds pretty fast!

I'll run a two 200 models production runs and let you know what I found.